ksb-d08-k0004

name: "KSB-D08-K0004" description: "Signal Prioritization Framework: Public health impact assessment, frequency and severity weighting, vulnerable population considerati..." version: "1.0.0" domain: "D08" domain_name: "Signal Detection & Management" type: "Knowledge" proficiency_level: "L4" bloom_level: "evaluate" triggers: - "explain signal prioritization framework" - "what is signal prioritization framework" - "evaluate signal prioritization framework" epa_mapping: "EPA-04, EPA-05" cpa_mapping: "CPA-02" regulatory_refs: "FDA-GUID-006, EMA-GVP-005, EMA-GVP-010, CIOMS-VIII"

KSB-D08-K0004: Signal Prioritization Framework

Overview

Domain: D08 - Signal Detection & Management Type: Knowledge Proficiency Level: L4 (Proficient - Independent practice) Bloom Level: Evaluate

Description

Public health impact assessment, frequency and severity weighting, vulnerable population considerations, regulatory action probability evaluation

Context

• Major Section: Signal Detection Theoretical Foundation and Methodological Framework
• Section: Signal Definition and Classification Systems

EPA Mapping

• EPA-04:3009-3010
• EPA-05:3011-3012

CPA Pathway

• CPA-02

Regulatory References

• FDA-GUID-006
• EMA-GVP-005
• EMA-GVP-010
• CIOMS-VIII

Instructions

When this skill is activated, Claude should:

1. Demonstrate L4 proficiency in signal prioritization framework
2. Apply evaluate level cognitive skills to evaluate the topic
3. Reference relevant regulatory guidance (FDA-GUID-006, EMA-GVP-005, EMA-GVP-010, CIOMS-VIII)
4. Connect to related EPAs: EPA-04, EPA-05

Key Competencies

• Public health impact assessment, frequency and severity weighting, vulnerable population considerations, regulatory action probability evaluation

Assessment Criteria

• Can evaluate core concepts independently
• Demonstrates understanding of regulatory context
• Applies knowledge appropriately to PV scenarios

Related Skills

• Other D08 skills in Signal Definition and Classification Systems
• Cross-domain integrations per DAG architecture

Generated from PV KSB Framework v1.0 | 2025-12-31