ksb-d02-k0010

name: "KSB-D02-K0010" description: "Drug-Disease Interactions: Impact of comorbidities on drug safety profiles..." version: "1.0.0" domain: "D02" domain_name: "Clinical Aspects of ADRs" type: "Knowledge" proficiency_level: "L3" bloom_level: "apply" triggers: - "explain drug-disease interactions" - "what is drug-disease interactions" - "apply drug-disease interactions" epa_mapping: "EPA-01, EPA-02, EPA-05" cpa_mapping: "CPA-01, CPA-02" regulatory_refs: "ICH-E2A, FDA-GUID-001"

KSB-D02-K0010: Drug-Disease Interactions

Overview

Domain: D02 - Clinical Aspects of ADRs Type: Knowledge Proficiency Level: L3 (Competent - Minimal supervision) Bloom Level: Apply

Description

Impact of comorbidities on drug safety profiles

Context

• Major Section: ADR Classification Systems
• Section: Pharmacological Mechanisms

EPA Mapping

• EPA-01:3001-3003
• EPA-02:3004-3005
• EPA-05:3011-3012

CPA Pathway

• CPA-01, CPA-02

Regulatory References

• ICH-E2A
• FDA-GUID-001

Instructions

When this skill is activated, Claude should:

1. Demonstrate L3 proficiency in drug-disease interactions
2. Apply apply level cognitive skills to apply the topic
3. Reference relevant regulatory guidance (ICH-E2A, FDA-GUID-001)
4. Connect to related EPAs: EPA-01, EPA-02, EPA-05

Key Competencies

• Impact of comorbidities on drug safety profiles

Assessment Criteria

• Can apply core concepts independently
• Demonstrates understanding of regulatory context
• Applies knowledge appropriately to PV scenarios

Related Skills

• Other D02 skills in Pharmacological Mechanisms
• Cross-domain integrations per DAG architecture

Generated from PV KSB Framework v1.0 | 2025-12-31