survival-design-routing - SKILL.md Agent Skill

name: survival-design-routing description: Choose the appropriate gsDesign survival or exact-binomial workflow when requests involve calendar-time interim analyses, event- or information-driven survival looks, seasonal rare-event exact-binomial monitoring, or explicit randomization ratios; covers when to use gsSurvCalendar(), gsSurv(), simBinomialSeasonalExact(), and toBinomialExact().

If a request specifies analyses by calendar dates or months from trial start or enrollment opening, use gsSurvCalendar(calendarTime = ...). Example: "add an interim analysis 24 months after enrollment opens" means include 24 in calendarTime.
When changing only analysis timing, preserve the original design specifications unless the user asks to change them.
Use gsSurv() when timing is event-driven or specified by information fractions rather than fixed calendar times.
Very low planned event counts, such as fewer than 100 total events, can be a cue to discuss exact-binomial rare-event methods, but do not switch solely because counts are low.
Use simBinomialSeasonalExact() and toBinomialExact() when the endpoint/workflow is seasonal rare-event exact-binomial monitoring; otherwise keep the appropriate survival design function.
Set ratio explicitly when randomization is specified; ratio = 1 means equal experimental:control randomization.