381,784 Collected SKILL.md files

Explore AI Agent Skills & Claude Prompts

Discover open-source agent skills for Claude Code, Codex, ChatGPT, and any tool that uses SKILL.md.

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biological technicians 194021
Showing 12 of 92 skills
mims-harvard

tooluniverse-image-analysis

by mims-harvard
star 1.5k

Microscopy and quantitative imaging analysis — colony morphometry, fluorescence intensity quantification, cell-count statistics, dose-response curves, and ANOVA/Dunnett on image-derived measurements. Uses pandas/numpy/scipy/scikit-image. Use for analyzing tabular outputs from CellProfiler/ImageJ, image-derived measurement statistics, and image-based assay quantification.

navigation main article SKILL.md
schedule Updated 1 month ago
aipoch

reagent-expiry-alert

by aipoch
star 1.2k

Scan reagent barcodes or IDs, log expiration dates, and generate multi-level alerts before reagent expiry to support laboratory inventory management.

navigation main article SKILL.md
schedule Updated 1 month ago
zjunlp

scienceworld-conditional-focus-executor

by zjunlp
star 1.0k

Executes a 'focus on OBJ' action on a specific object based on the outcome of a prior conditional evaluation. Use when you have a measurement result and task instructions specify focusing on different objects (e.g., colored boxes) depending on whether the result meets a threshold.

navigation main article SKILL.md
schedule Updated 3 months ago
zjunlp

scienceworld-circuit-builder

by zjunlp
star 1.0k

This skill constructs a simple electrical circuit by connecting components like batteries, wires, and light bulbs. Use when the agent needs to test electrical conductivity or create a functional circuit for an experiment. The input is a set of available components, and the output is a fully connected circuit ready for activation.

navigation main article SKILL.md
schedule Updated 3 months ago
beita6969

protocol-writing

by beita6969
star 850

# Protocol Writing — Reproducible Lab Protocols & SOPs

navigation main article SKILL.md
schedule Updated 3 months ago
SpectrAI-Initiative

drugsda-data-valid

by SpectrAI-Initiative
star 379

Check if the input protein sequence or molecule SMILES string is valid.

navigation main article SKILL.md
schedule Updated 2 months ago
SpectrAI-Initiative

lab-protocol-from-literature

by SpectrAI-Initiative
star 379

Lab Protocol from Literature - Extract and generate lab protocol: search PubMed, extract protocol from paper, and generate executable protocol. Use this skill for lab science tasks involving pubmed search extract protocol from pdf protocol generation generate executable json. Combines 4 tools from 2 SCP server(s).

navigation main article SKILL.md
schedule Updated 2 months ago
SpectrAI-Initiative

protocol-extraction-from-pdf

by SpectrAI-Initiative
star 379

Extract laboratory protocols from PDF documents using Thoth-Plan to convert experimental procedures into structured text.

navigation main article SKILL.md
schedule Updated 2 months ago
SpectrAI-Initiative

protocol-to-executable-json

by SpectrAI-Initiative
star 379

Convert laboratory protocols to executable JSON format using Thoth-OP for automated lab equipment control.

navigation main article SKILL.md
schedule Updated 2 months ago
mkurman

protocolsio-integration

by mkurman
star 312

Integration with protocols.io API for managing scientific protocols. This skill should be used when working with protocols.io to search, create, update, or publish protocols; manage protocol steps and materials; handle discussions and comments; organize workspaces; upload and manage files; or integrate protocols.io functionality into workflows. Applicable for protocol discovery, collaborative protocol development, experiment tracking, lab protocol management, and scientific documentation.

navigation main article SKILL.md
schedule Updated 1 month ago
Microck

opentrons-integration

by Microck
star 238

Lab automation platform for Flex/OT-2 robots. Write Protocol API v2 protocols, liquid handling, hardware modules (heater-shaker, thermocycler), labware management, for automated pipetting workflows.

navigation main article SKILL.md
schedule Updated 1 month ago
DrugClaw

patent-landscape-tools

by DrugClaw
star 183

Drug-patent landscape workflow guide for searching US patents via the PatentsView API, classifying pharmaceutical claim types (NCE, formulation, method-of-use, polymorph, combination, biologic, process), grouping by patent family and assignee, estimating expiry timelines, and cross-referencing the FDA Orange Book for marketed-drug exclusivity windows. Use when the user asks about patent coverage, IP white-space, patent cliffs, or competitive filing activity around a drug, target, or compound class without asking for legal counsel.

navigation main article SKILL.md
schedule Updated 3 months ago
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Browse Agent Skills by Occupation

23 major groups · 867 SOC occupations

Browse by Category

Explore agent skills organized by their primary use case

SKILLMD / CREATORS AND OCCUPATION CATEGORIES

Explore the agent skills ecosystem by occupation and creator

SkillMD is not just a keyword search box. It is an open map that organizes public skills by occupation, creator, and repository, helping you see which workflows, judgment criteria, and domain habits people are writing for AI agents.

Then follow creators and GitHub repositories back to the source: compare the skills a team maintains, whether the repo is active, and how the README frames the work before you open, install, or reuse anything.

Use it three ways: learn an unfamiliar field by occupation, study how creators organize skills, then use source context to decide what is worth opening or reusing.

01 Map a field

Browse 23 occupation groups and 867 SOC roles to learn what skills exist in adjacent domains and how they break down real work.

02 Follow creators

Use creator and repository pages to inspect maintained skill collections, recent updates, and source context before trusting a result.

03 Search with sources

Search 1.7M+ collected skills, then use occupation tags, creators, and GitHub source context to decide what is worth opening.

Start with the occupation map, then follow creators and repositories back to real code. SkillMD helps explain why a skill is worth opening, not only what it is named.

SEO KNOWLEDGE HUB & TECHNICAL OVERVIEW

Standardizing Agent Capabilities with SKILL.md and Model Context Protocol (MCP)

In the rapidly evolving landscape of artificial intelligence, LLM agents (Large Language Model agents) have transitioned from simple text predictors to autonomous problem solvers. To orchestrate complex, multi-step agentic workflows, developers require a standardized format to specify agent capabilities, prompt instructions, system rules, and database bindings. This is where SKILL.md and the Model Context Protocol (MCP) have emerged as standard developer paradigms. SkillMD serves as the central directory for indexing, exploring, and sharing these critical agent configurations.

Our open-source registry currently tracks over 1.7 million collected SKILL.md configurations and system prompts. By compiling agent configurations from active developers on GitHub, we bridge the gap between prompt engineering research and production execution. Whether you are building agents with Anthropic's Claude Code, OpenAI's GPT-4, Google's Gemini, or local models using Ollama and LlamaIndex, standardized skill definitions ensure your agents behave predictably across different runtime environments.

What is the Model Context Protocol (MCP)?

The Model Context Protocol (MCP) is an open-source standard designed to connect LLMs to data sources, developer tools, and external environments. MCP establishes a bidirectional communication channel between client applications (like Cursor, Claude Desktop, or custom agent systems) and servers hosting data or capabilities. Standardizing instructions via SKILL.md enables LLMs to query databases, read local files, execute terminal commands, and integrate third-party APIs. SkillMD allows you to find ready-to-run MCP servers and prompt instructions for various occupations and technical tasks.

The Structure of a Professional SKILL.md File

A valid SKILL.md configuration is designed to be easily read by humans and parsed by LLMs. It contains precise system instructions, trigger conditions, required parameters, and execution examples. Below is the typical architectural blueprint of a professional agent skill:

  • Metadata & Core Scope: Declares the name of the skill, author details, target models, and a description of the capability.
  • Triggers & Intent Detection: Details semantic triggers that help the agent decide when to invoke this skill.
  • System Prompts: Explicit system-level instructions that direct the agent's behavior, personality, safety guardrails, and formatting preferences.
  • Capabilities & Tools: Lists the files, databases, or APIs the agent must access to complete the tasks.
  • Few-Shot Examples: Demonstrates real inputs and outputs, helping the model generalize behavior through in-context learning.

Optimizing Agent Workflows for Modern LLMs

Writing effective agent skills requires deep knowledge of prompt engineering. With the release of advanced reasoning models like Claude 3.5 Sonnet, ChatGPT o1, and DeepSeek-V3, prompt templates must focus on structured thinking. Developers are encouraged to use XML tags (e.g., <thought>, <context>, and <rules>) to isolate execution boundaries. Standardized prompts prevent agents from suffering from context drift, ensuring that long-running tasks remain aligned with the initial system parameters.

Exploring by SOC Occupations and Creator Profiles

What makes SkillMD unique is its taxonomy. Instead of simple text search, we parse and organize files according to the Standard Occupational Classification (SOC) system. This means you can discover skills written for Computer and Mathematical roles, Business and Financial operations, Legal, Design, and and Educational Instruction fields. By tracking creator profiles, developers can study how different teams organize their custom instructions, compare version updates, and fork public configs for specialized enterprise use cases.

SkillMD operates as a high-performance index running on a fast Go backend and a highly responsive Astro SSR frontend. All search queries execute in milliseconds, featuring smart debouncing to prevent multiple API requests while keeping user data secure. Join our community of developers to standardize your AI agent instructions and optimize your LLM prompting workflows today.

8 QUESTIONS

Frequently Asked Questions

A practical guide to agent skills: what they are, how to inspect them, and how SkillMD helps you explore the ecosystem.